Fish Gill Cell Culture System, MCB263 science communication assignment

My tweet for this week’s MCB263 science communication assignment is about a new technique by researchers at King’s College London, published in Nature Protocols, using freshwater gill tissue in culture as a proxy for in vivo fish gill tissue which is commonly used in toxicity testing to assess whether compounds have negative biological effects. Since gill tissue is designed to filter water and extract oxygen and osmolytes for the fish, it is a great method for measuring toxicity of compounds in water since they get trapped in the gill tissue. In this fish gill cell culture system by Schnell et al. (2016), whole fish do not have to be sacrificed for this purpose. Instead, only the gill tissue is used to assess potential toxicity, bioaccumulation, or environmental monitoring. Not only is this system resource-efficient and portable, only requiring a thin layer of tissue and some reagents to maintain, but it does not require raising and maintaining whole animals. The elegant features of gill tissue can be used without waste.

This video demonstrates the technique:

My group’s tweets:

Laura Perilla-Henao: market resistance to synthetic malaria drug

Ryan KawakitaE. coli used to generate morphine precursor

Stephanie Fung: researchers publish in Cell exploring microbiome evolution from hunter-gather to modern western society

Prema Karunanithi: release of real-time data on Zika virus infection study in monkeys


About Lisa Johnson

PhD candidate at UC Davis in Molecular, Cellular, and Integrative Physiology
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